The pan-genomic model is being developed by Peter Cook,
Davide Marenduzzo (University of Edinburgh), and colleagues.
It applies to all organisms, and posits that
every base-pair in a genome affects
the activity of every other base-pair
to some degree.
The fundamental structural feature is
a cluster of active RNA polymerases and
associated factors – a ‘transcription factory’.
Factories anchor surrounding loops and
organize TADs + A/B compartments.
We were all taught that
active RNA polymerases act alone as they
track like locomotives down their templates
(what is the evidence?).
We imagine they are clustered in factories
and transiently immobile as they reel in their
templates and extrude transcripts.
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