The pan-genomic model

See mini-review

+ 8 YouTube videos.

The model is being developed by Peter Cook,

Davide Marenduzzo (University of Edinburgh), and colleagues.

It applies to all organisms, and posits that

every base-pair in a genome affects

the activity of every other base-pair

to some degree.

The fundamental structural feature is

a cluster of active RNA polymerases and

associated factors – a ‘transcription factory’.

Factories anchor surrounding loops and

organize TADs + A/B compartments.

We were all taught that 

active RNA polymerases act alone as they

track like locomotives down their templates

(what is the evidence?).

We imagine they are clustered in factories

and transiently immobile as they reel in their

templates and extrude transcripts.

Videos:

1  Key principles

2  Classical mechanism

3  Small-world networks

4  Transcription factories

5  How regulatory motifs work

6  A simple formula

7  Conclusions

8  FAQs